Job Description

FIG (Factor Induced Gene) Therapeutics, Inc. is a preclinical stage biotech company developing a proprietary intratumorally delivered polynucleotide that hijacks cancer-causing machinery to drive secretion of a multimodal immunotherapy that modulates more mechanisms of the immunosuppressive tumor microenvironment than any prior therapyat a fraction of the cost.

Role summary

We are hiring a hands-on Principal Scientist to lead and execute the majority of our pre-IND in vitro and in vivo work. This role is lab-forward and IND-driven: you will design, develop, run, qualify, document, and present assays and preclinical studies that support IND filing and early CRO/GLP programs. The position is onsite in Valhalla, NY (5 days/week). You will be working closely with and directly reporting to the founder and CEO.

The candidate must have a PhD in a related field with a proven track record in in-vitro assay development and solid tumor immunotherapy research in humanized CD34+ PDX mouse models.

Applicants must be authorized to work in the United States without sponsorship. Employment offers are contingent on satisfactory completion of post-offer background checks and any legally required pre-employment screenings. Where applicable, FIG Therapeutics will comply with the Fair Chance Act, New York Clean Slate Act, and other relevant laws regarding criminal history and background checks; criminal-history inquiries or checks will be conducted only after a conditional offer as required by law. Pre-employment testing for cannabis/THC will be performed only where legally permitted or required (for example, federal/DOT or other safety-sensitive exemptions).

Non-negotiable: Applicants must have performed each item in the Must-Have qualifications list within the last 18 months. If you do not meet every Must-Have item in the past 18 months, please do not apply.

MUST-HAVE qualifications (all performed within the last 18 months)

• Hands-on generation of CD34 humanized mice AND direct experience implanting/maintaining prostate PDX tumors
• Intratumoral injection and in vivo transfection optimization of PDX tumors
• Surgical tumor resection/necropsy with downstream tissue processing (IHC/IF and flow)
• Expertise in rational design of lipid nanoparticles for plasmid DNA delivery
• Viral vector (adenovirus and HSV), RNA, and polycistronic DNA plasmid design
• Cell culture and transfection/transduction of primary tumor cells, T cells, and cancer cell lines
• Development of cancer and immune cell co-culture assays
• Establishment of 3D organoid models of solid tumor TME
• Assay development for multicolor flow cytometry panels, ELISA, Luminex, ELISPOT, RT-qPCR, and digital PCR (dPCR)
• Proven ability to independently design experiments, troubleshoot complex failures, and author SOPs and study reports used to inform CRO/IND decisions
• Experience coordinating with CROs on GLP-style biodistribution/toxicity/TK studies and contributing to study plans
• Previous track record of IND support (authoring preclinical sections) and interactions with regulatory consultants.

Key responsibilities

• Design, optimize, and run in-vitro potency & functional assays for multi-domain immune effectors
• Develop and validate quantitative assays: RT-qPCR, digital PCR (dPCR), ELISA, Luminex multiplex cytokine panels, ELISPOT, Western blot.
• Build, optimize and analyze multicolor flow cytometry panels (immunophenotyping, T-cell activation, exhaustion markers, Treg analysis) and perform associated data analysis (FlowJo/Cytobank/others).
• Run in-vitro immune function assays: PBMC cytotoxicity, NK/ADCC, DC activation, antigen-presentation readouts.
• Establish and run TME models: 2D, 3D spheroids/organoids, tumor:immune co-cultures; provide assay qualification (precision, accuracy, dynamic range).
• Lead in vivo programs: generation and management of CD34 humanized mice, engraftment of patient-derived prostate xenografts (PDX), tumor implantation, intratumoral injection dosing, surgical resection, necropsy, tissue processing for flow/IHC/IF and molecular readouts.
• Design and execute GLP-style biodistribution, PK/PD, and toxicology study plans in collaboration with CROs; write and review study protocols and reports for IND packages.
• Author SOPs, experimental design docs, technical reports, and contribute to IND-enabling documentation.
• Maintain rigorous data integrity, sample tracking, and reagent QC; assist with reagent sourcing, vendor qualification and basic CMC input.
• Mentor and coordinate work with any junior scientists/technicians and external CRO teams.

Salary Range: $80,000$120,000/year

Competitive benefits package, including health insurance, PTO, and stock options.

Application instructions & required verification materials

All of the following is required to be considered for the role. Please note that the Cover Letter and CV may need to both be within a single PDF document and uploaded under resume (LinkedIn sometimes does not provide option to upload Cover Letter separately):

• Curriculum vitae (with dates and affiliations).
• Cover letter that demonstrates your understanding of what is required of your role as the first non-founder scientist hire in a small biotech company. It must also explicitly map out how you meet each Must-Have item and provide dates (month/year) and employer/lab for each activity.
• Three professional references (name, title, phone, e-mail) who can verify the required experiences performed.
• Permission to perform background check and employment verification. Applicants must be willing to sign a declaration confirming that the supplied information is true and accurate.

Applications that do not include the above verification materials will be rejected.

Strict verification & disqualification policy

FIG Therapeutics requires all applicants to have performed each Must-Have activity within the 18 months prior to application and to provide documentary evidence and references verifying those activities. By submitting an application you certify that the information you provide is true and accurate to the best of your knowledge. Offers are contingent upon satisfactory verification of employment, education, references, and any required background checks. Any material misrepresentation or omission may result in withdrawal of an offer or termination consistent with law. FIG Therapeutics will follow applicable state procedures when considering criminal-history information and will provide required notices where applicable.

Equal Employment Opportunity & Workplace Policy

FIG Therapeutics is an equal opportunity employer. We are committed to providing a workplace free of unlawful discrimination and harassment. All employment decisions are made without regard to race, color, religion, creed, sex, gender, gender identity or expression, sexual orientation, national origin, ancestry, citizenship status, age, marital status, pregnancy, childbirth or related medical conditions, domestic violence victim status, veteran or military status, disability, genetic predisposition or carrier status, or any other status protected by federal, state, or local law.

FIG Therapeutics complies with New York State law regarding criminal history, including Article 23-A and the Clean Slate Act (automatic record sealing). We will not rely on sealed convictions and will provide any required notices and an opportunity to respond prior to taking adverse action.

FIG Therapeutics will provide reasonable accommodations for qualified individuals with disabilities and for applicants who require assistance to participate in the application/interview process. If you require an accommodation, please indicate such in your cover letter. Alternatively, if you prefer confidential email contact, please note that in your cover letter and we will provide an address for private correspondence. We will treat accommodation requests confidentially and will respond promptly.

Seniority level

• Seniority level

  Mid-Senior level

Employment type

• Employment type

  Full-time

Job function

• Job function

  Research, Analyst, and Information Technology

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